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This structural modification significantly reduces its affinity for IGF binding proteins (IGFBPs), increases the free concentration, and enhances its biological activity by more than three times compared to natural IGF-1

Journal (World Journal of Gastroenterology, Jan 7, 2022, 28(1), 2346)

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Control and shame, coincidentally, feature strongly in the mindsets of those with eating disorders, notes Debra Safer, a psychiatrist at Stanfords medical weight loss clinic