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Finally, the hydrolysis with 18% hydrochloric acid, in the presence of dioxane at 60C, afforded semisquaric acid of 90% yield [96]

4 Regulatory mechanisms of L-carnitine on hepatocyte function Clinical evidence indicates that L-carnitine improves liver function in NAFLD patients, reflected by reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels ( treatment for 12 weeks significantly improved liver enzymes ( Human studies further corroborate these findings