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In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines
Inclusion and exclusion criteria The following criteria were used to determine which studies were eligible based on the PICOS principles 32 : 1) participants were aged 18 years with a diagnosis of AD or with cognitive impairment without a diagnosis of AD
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Some researchers have also used plasma Insulin levels with the immunometric assay technology or GLP-1 levels to diagnose PH [26]
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