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NRF2 expression was markedly decreased in NSC-34 motor neuron cells transfected with the human SOD1 G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4

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As anticipated, the gsh strain exhibited a substantial 40% decrease in total glutathione content compared to the WT, primarily due to a twofold reduction in the levels of GSH (Fig

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The prescribed frequency and dosage vary from peptide to peptide

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)