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Remarkably, tirzepatide (15 mg per week) reduced body weight by up to 20.9% after 72 weeks [93], which was associated with reduced waist circumference and an overall improvement in individuals clinical profile

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Subsequent rises in IGF-1 concentrations were noted, persisting for one to two weeks, with prolonged activity observed in repeated exposures

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22 Variations in formulation, dosing schedules, and dual agonism with tirzepatide influence tolerability, emphasizing the need for individualized therapy