Rhonda Patrick: I am so excited to be here having a conversation with you, so thank you
Clinical priorities may include weight loss, avoidance of hypoglycemia, desired magnitude of glucose lowering, cost, side-effect profile, possibility of pregnancy, and comorbidities [Grade D, Consensus]
Concomitant medications that alter protein binding or renal blood flow can prolong the tail, and dehydration reduces renal perfusion, which slows excretion and increases variability
GLP-1, for instance, slows down how fast food leaves the stomach
Promising CV safety with 49% all-cause mortality & 51% CV death reduction for non- Inferiority
Meaning, people who were using compounded semaglutide to save money on the high cost of Ozempic will have to purchase the brand-name drug