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By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes
Everything known about it comes from cell cultures and rodents
It is found in every cell in the body and is made from three amino acids - glycine, cysteine and glutamic acid
Transitioning between formulations differs on a case-by-case basis
40 units of semaglutide is 1.0 mg at a concentration of 2.5 mg/mL, 0.8 mg at 2 mg/mL, 0.4 mg at 1 mg/mL, or 2.0 mg at 5 mg/mL
Monitoring differences Patients on Toujeo need regular blood glucose monitoring, including fasting glucose checks and possibly continuous glucose monitoring
