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At the highest dose (3/6/9/12 mg escalation scheme), mean HbA1c was reduced by up to 1.6% and weight by nearly 9 kg, which was significantly greater than placebo
When lifestyle modifications prove insufficient, pharmacological intervention becomes necessary to manage semaglutide-related constipation
Results: Mean (range) baseline characteristics of the 957 treated subjects (35% male) were: age 47 (18-86) years, weight 111 (70-244) kg, body mass index 39 (30-80) kg/m2, NFS -0.49 (-4.70 to 4.66), and FIB-4 0.72 (0.14-3.31)
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