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Further incretin-based drug development For both GIP and GLP-1, positive effects were also observed on cardiovascular complications [23], indicating a therapeutic potential beyond the improvement of diabetes complications

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These cells possess various receptors and transporters on their surface that recognise specific nutrients, particularly glucose, fatty acids, and amino acids

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Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

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