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During inflammation, GSH neutralizes reactive oxygen species (ROS), preventing oxidative damage to immune cells (8)
Strikingly, simply increasing mitochondrial GSH levels by expressing mito-GSHf in SLC25A39/40 double knockout cells completely restored the reduced levels of mitochondrial translation machinery proteins, iron-sulfur containing proteins, and aconitase activity (Fig 4f,g)
10.3390/ijms15010171 78 LocattoV.DePintoM
6 Conclusions and perspectives The pathophysiological mechanisms of DR are highly complex
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