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The phase 2 trial tested multiple dose levels over 52 weeks

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Double-immunofluorescence staining of GLP-1R and -smooth muscle actin (-SMA) in kidney sections confirmed the absence of GLP-1R expression in VSMCs of Glp1r VSM/ mice (Figure 1M)

REDEFINE-1: adults with obesity, no diabetes Design: 3,417 adults with BMI 30 (or 27 with a comorbidity), without type 2 diabetes, for 68 weeks

Everyone should avoid self-directed or unsupervised use of GLP-1 medications, no matter the dose