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Tirzepatide products such as Mounjaro and Zepbound are not included in the GLP-1 RA Summary Safety Review, which is scoped to the five molecules listed above

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Inducible reporter assays, especially luciferase reporters, which are linked to the activation of specific signaling pathways for example by the GIP receptor, provide a reliable measurement of the inhibitory or activating effect of substances on diabetes-associated cell signaling pathways (Fig