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Tumor suppressors RBL1 and PTEN are epigenetically silenced in IPF mesenchymal progenitor cells by a CD44/Brg1/PRMT5 regulatory complex

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Plasma levels remain elevated for 45 days after the final dose, though receptor-mediated effects diminish as concentration drops below the activation threshold

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

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