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TAS, RKC, IK and MH drafted the manuscript
Theories on how GLP-1 can prevent beta cell apoptosis, and possibly cause beta cell regeneration and proliferation: GLP-1 inhibits apoptosis Farilla and colleagues, demonstrated in their studies with the isolated human islets, which were separated into groups of those with and without GLP-1
A power analysis ( = 0.05 and power = 0.90), based on data where a difference would be significant if the weight loss were 1 kg more than that in CT group with an expected standard deviation of 0.75, indicated that 13 patients would be needed in each group to detect significant difference [18]
Change in urinary frequency is valuable to evaluate response to therapy but is of little help in diagnosis
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