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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

Supplementary material The Supplementary material for this article can be found online at: Footnotes References 1 AbdullahN

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Complex pharmacological animal models suggest that the peptide interacts intricately with multiple neurotransmitter networks, including the dopaminergic, serotonergic, GABAergic, and opioid systems