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SM, Pinheiro JJ, Tuji FM

The orexigenic action of ghrelin is mediated through direct stimulation of the orexigenic AgRP/NPY neurons and concomitant inhibition of the anorectic POMC/CART neurons in the ARC (143, 144)

These symptoms typically emerge during dose escalation and often diminish over several weeks as tolerance develops

Some of the conditions that they treat include depression, substance abuse and anxiety disorders