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The number of carboxylate groups at the surface of the biomass was reduced upon the methylation, and new functional groups such as ether (-C-OCH 3 ), amines (-NH 2 , -NHR), and "free" carboxy groups (-COOH) emerged which significantly enhanced the biosorption efficiency (Malletzidou et al
246 Therefore, obesity seems to be a double-edged sword for cancer immunotherapy, and the underlying mechanisms remain unclear and require further investigation
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