glp-1 dopamine Glucagon-like peptide 1 receptor activation regulates cocaine actions and homeostasis in the lateral septum by decreasing arachidonic acid levels Schematic drawing of reversed reward

To become a "blockbuster," it must meet efficacy (big mean body weight loss), tolerability (fewer side effects), and something unique, such as dosing convenience (oral delivery and once-a-month shot)

These cascades function cooperatively to promote hepatocyte survival and replication during regeneration

Given the significant therapeutic value of this mechanism, we pursued a novel high-throughput creening (HTS) strategy that identified a series of small-molecule fluoropyrimidine-based GLP-1R agonists

doi:10.1016/S0736-0266(03)00110-4 Goldstein AL, Hannappel E, Sosne G, Kleinman HK

Antioxidant Properties Of Glutathione Glutathione protects the body from free radicals

Wawrzyniak NR, Joseph AM, Levin DG, et al