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Introduction Medications that target and downregulate the immune system are utilized for the prevention and treatment of a variety of conditions, including neoplasms, autoimmune diseases, and acute rejection after solid organ transplantation (Figure 1)

The authors also thank Traci Raley, MS, ELS, from Liwen Bianji (Edanz) (www.liwenbianji.cn) for editing a draft of this manuscript