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Once secreted, both endogenous GIP and GLP-1 undergo rapid degradation into the biologically inactive metabolites (50, 51)
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This dual-pathway approach augments GH pulse amplitude through the GHRH axis while the ghrelin pathway contributes additional stimulatory drive, together producing amplified, physiologically representative GH secretion events
Ethics approval and consent to participate This study was reviewed by the Natural and Non-prescription Health Products Directorate (NNHPD), Health Canada and a research ethics board, which granted ethics approval in December, 2014
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