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Small molecule positive allosteric modulators (PAMs) offer a promising alternative to peptide-based drugs currently on the market which suffer from poor oral bioavailability
Historically, Medicare excluded drugs prescribed solely for weight loss, weight gain, or appetite suppression, which has shaped the current market
However, it is essential to approach these medications with caution and under the guidance of a healthcare provider
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The administration of such agents could therefore be: (1) inappropriate and should not be prescribed off-label in type 1 diabetes
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