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In tissue-repair research, angiogenesis matters because new blood vessels are what deliver oxygen and nutrients to the area being repaired

Several randomized, placebo-controlled trials indicate that metformin therapy leads to a progressive decline in vitamin B12 levels and can cause physiologically significant deficiency (153)

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Its also needed for fatty acid metabolism and amino acid metabolism , which are key for energy and healthy tissues

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Symptoms of a B12 Deficiency in Cats lethargy vomitting off food / weight loss confused trouble walking or jumping Does Your Cat Need B12 shots