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New England Journal of Medicine, 389 (6), 514526
However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]
Incidence of potential adverse events during hospital-based ketogenic diet initiation among children with drug-resistant epilepsy
It has also been reported that liraglutide increases neural stem cell proliferation and neuronal differentiation in the APP/PS1 neurodegenerative disease model (Parthsarathy and Holscher, 2013a)
The key to safe GLP-1 use involves proper medical supervision, gradual dose escalation, and open communication with your healthcare provider about any concerns
Thats where the challenge begins
