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"There will be a small proportion of people, 10% maximum, that are able to maintain [all] the weight they've lost," says Alex Miras, a clinical professor of medicine at Ulster University

How Semaglutide Works Semaglutide binds to GLP-1 receptors throughout the body, producing several coordinated effects that promote weight loss and metabolic health (3): Appetite suppression: Acts on hypothalamic appetite centers to reduce hunger and increase satiety Delayed gastric emptying: Slows the rate at which food leaves the stomach, promoting longer-lasting fullness Enhanced insulin secretion: Stimulates glucose-dependent insulin release, improving blood sugar control Reduced glucagon secretion: Lowers the hormone that raises blood sugar levels Central reward pathway modulation: May reduce food cravings and reward-driven eating behavior Semaglutide for weight loss is administered as a once-weekly subcutaneous injection with a gradual dose escalation from 0.25 mg to a target dose of 2.4 mg over 16 to 20 weeks

This "protective envelope" serves two purposes

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Regular physical activity is encouraged alongside Wegovy treatment