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These factors often combine to create the constipation that many semaglutide users report
Disinhibited eating, characterized by loss of control around food, showed significant improvement in trial participants
The kidneys filter water-soluble metabolites
Additionally, the degree of appetite reduction may plateau or diminish slightly over time as physiological adaptation occurs, though clinical efficacy generally persists with continued use
The phase 2 trial published in the New England Journal of Medicine used a BMI cutoff of 30 or higher
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