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Chronic inflammation, oxidative stress, and ferroptosis are thought to induce chondrocytes to excessively generate catabolic factors, resulting in the degradation of chondrocytes and ECM, hence accelerating the degeneration of articular cartilage in OA [41-46]

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If irritation appears, the first step is usually to reduce frequency or pause use, allow the skin to recover, and reintroduce cautiously

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