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Although vitamin B12 is naturally found in animal products such as meat, dairy, and eggs, some people may be unhappy with a vitamin B12 deficiency due to diet, health, or age

SAMe donates methyl groups to DNA, RNA, and proteins, producing S-adenosyl-homocysteine (SAH)

Frequency and duration are other critical variables

If the vial can hold 5 mL, that water volume halves the concentration from 32 mg/mL to 16 mg/mL and may reduce the copper-peptide sting

Researchers using the combination should be aware of this potential effect, particularly at higher retatrutide doses