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Indeed, carcinogenicity studies in rats and mice have demonstrated a dose- and time-dependent increased risk of medullary thyroid carcinoma (MTC) with GLP-1 RAs [11,12]

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JAMA Ophthalmol 132(6):737741 Cohen EJ (2009) The case against the use of steroids in the treatment of bacterial keratitis

Absolute contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN2) Known hypersensitivity to the medication or its components These are based on boxed warnings and prescribing information and should be treated as non-negotiable