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GIP receptor activation at low doses supports mitochondrial function in adipose tissue and may contribute to improved fatty acid metabolism independent of the dramatic appetite suppression seen at full doses

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Gastrointestinal symptoms typically improve over time as the body adapts to the medication, though the timeframe varies between individuals

Further research has been conducted in order to see how various GH-stimulating peptides, such as modified GRF 1-29, can have positive benefits on the gut without negative side effects

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however, the medication is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2