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SDC-1 binds to HS and CS, while GPC-1 contains only an HS chain and lacks CS [26]

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People who should not use GLP-1s include: Pregnant people People with a personal or family history of medullary thyroid cancer People with multiple endocrine neoplasia syndrome type 2, a rare condition that affects the endocrine glands People who are hypersensitive to GLP-1 agonist drugs GLP-1 Drugs Are Lifelong Treatments Questions to Ask Your Doctor Am I a candidate for a GLP-1 weight loss drug

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April 2025: Another study showed how semaglutide use may lead to a higher risk of vision impairment compared to other GLP-1 RA medications

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