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Loren Pickart estimated that toxic effects would begin at approximately 22,500 mg, which represents a 300-fold margin above effective therapeutic doses

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in fact, caffeine can transiently raise adrenaline which might nudge blood sugar up a tiny bit, but not significantly for most

R.M.R was supported by the Australian Government through an Australian Research Council Future Fellowship (FT220100717)

This may help protect against future issues