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[3] : 313 The most common cause in developed countries is impaired absorption due to loss of gastric intrinsic factor (IF), required for absorption
Cyanocobalamin is a stable, synthetic form of B12
Lab tests show pp 332 activation leads to suppression of lipogenic gene expression and activation of genes involved in mitochondrial biogenesis
For other confirmed or suspected malabsorption, vitamin B12 replacement should be offered and intramuscular treatment should be considered instead of oral treatment
On the other hand VEGF is researched for its role in angiogenesis, the formation of new blood vessels from pre-existing vessels
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