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Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

However, in conditions in which these cells are dysfunctional or overactive, they can cause serious issues

Ipamorelin studies are lacking overall and this merits further research, but what limited data exists suggests that ipamorelin offers some promising benefits in the area of body composition and recovery rates

gastrointestinal side effects and dose-dependent tolerability issues were the most notable findings, and Phase 3 trials are needed before regulatory submission

Development 126(10):20332044 Adams RH, Klein R (2000) Eph receptors and ephrin ligands