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Experimental studies suggest that AST may enhance autophagy and proteasome function, thereby facilitating the clearance of misfolded proteins and limiting cellular stress
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Goderie T, van Wier MF, Lissenberg-Witte BI, Merkus P, Smits C, Leemans CR, Kramer SE
Combine it in the same chamber with a vitamin C serum (typically pH 3.0 to 3.5) and the copper ion oxidizes the ascorbic acid
Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]
