surmount-1 trial tirzepatide weight loss nondiabetic for the Maintenance of Body Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN - Horn - 2025 - Obesity SURPASS to SURMOUNT: The Tirzepatide

Women who maintained consistent supplementation (80% adherence) experienced 24% fracture risk reduction -- twice the benefit of inconsistent users

He says there's very little data on whether or how the dose should be titrated to wean patients off, or how to adjust when your appetite and cravings start to return

There may be a short plateau - As your body will be dealing with a new mechanism, it may take 2-4 weeks to get used to it

When eating doesnt feel good, you might skip meals, eat very little, wait longer to eat, or reach for bland comfort foods that arent necessarily nutritious

Missing doses or irregular administration patterns may prevent steady therapeutic levels, reducing appetite suppression

When stomach acid travels back up the esophagus, it can irritate the throat and nasal passages, leading to a runny nose, postnasal drip, or a persistent cough