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Systemic Side Effects Gastrointestinal Side Effects The most commonly reported side effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspepsia [113,114,115]

This mechanism is why slow-release carbohydrates and prebiotic fibers are increasingly positioned to raise endogenous GLP-1 and PYY as a non-drug route to appetite regulation

They play a crucial role in the development of metabolic diseases [6, 7]

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Practically speaking, if 20 out of 100 women with PCOS in the control group conceived naturally, approximately 34 out of 100 women taking GLP-1s would conceivean additional 14 pregnancies per 100 women

This includes elevated LDL cholesterol, elevated triglycerides, or low HDL cholesterol