Proteomic identification of nitrated proteins in Alzheimers disease brain
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Bettermann EL, et al
Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig
Figure 7 diagrams how such interventions have been applied in different organs (heart, brain, kidney) and what outcomes have been observed or expected, bridging mechanism to clinical translation
Corsini E, Mitchell K, Mehran R, Rice D, b S, Walsh G, Swisher SG , Roth J, Hofstetter W, Vaporciyan A, Morris V, Antonoff M