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CCL3 promotes leukocyte recruitment via CCR5 signalling, which has been shown to inhibit long-term potentiation due to an attenuation of MAPK/CREB signalling and diminished hippocampal synaptic transmission, thereby contributing to cognitive impairment and neurodegeneration [204]

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This neurological shift often proves more sustainable than traditional diet-and-exercise approaches alone

However, due to rapid degradation by DPP-4, GLP-1/2 and GIP have short half-lives, with 1-2 minutes for GLP-1/2 and 7 minutes for GIP (18, 41)

After 30 years, cardiovascular mortality rates for liraglutide 1.2 mg, 1.8 mg, and rosiglitazone reached 69.7%, 68.4%, and 72.5%