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Significant reductions in subcutaneous fat can alter skin tension, hydration, and barrier function, which may manifest as dryness, sensitivity, or a sensation of tightness

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ATTAIN-2 (NCT05872620) was a Phase III, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of various doses of orforglipron with placebo in adults with obesity or overweight and type 2 diabetes

For someone already managing endo belly, this worsening period can feel like a disease flare

But people are using it today through three routes, listed from most legitimate to least: 1