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On June 29, 2023, in response to these concerns, the American Society of Anesthesiologists (ASA) issued consensus-based guidance regarding preoperative management of patients who are taking GLP-1 receptor agonists

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non-oral contraception or backup methods are recommended for 4 weeks after starting tirzepatide or increasing the dose

They bind to GLP-1 receptors and activate them, providing the same benefits as the natural hormone but with a longer duration of action

Failing to do so may result in enforcement actions and potential liability under consumer protection laws

Dietary carnitine intake greatly reduced (5-30 mg/day vs 60-180 in omnivores)