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Tirzepatide's added GIP activity is thought to drive the larger effect on top of the shared GLP-1 pathway though weight loss is only one part of the picture, and semaglutide still has the longer cardiovascular-outcomes track record (more on that below)

One of his previous studies looked at how the type 2 diabetes drug liraglutide could work in those with type 1

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For instance, when GLP-1 drugs are combined with insulin or sulfonylureas, it can increase the risk of hypoglycemia

It means their value lies in metabolic support, not in being nature's Ozempic. Berberine: The Most Studied Candidate Berberine is a yellow alkaloid compound found in plants like goldenseal, Oregon grape and barberry