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These individuals should consult with a doctor first before taking a vitamin B12 supplement

Any discomfort is easily treated with over-the-counter pain medication, allowing patients to jump back into their activities without hesitation

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See the 2026 updates section of this guide for the complete breakdown with source citations

In contrast, a B12 injection (typically administered into a muscle, known as an intramuscular injection) bypasses the entire digestive system

For instance, a patient with borderline low B-vitamin levels might receive 0.5 mL IM weekly, whereas someone with severe malabsorption could receive 1-2 mL IM two to three times per week initially