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In terms of mechanism, molecular hydrogen activates the activities of key antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), which promote ROS clearance [35]

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They may experience oxidative stress in pulmonary capillaries or osmotic shock in the renal vasculature

Patients with major depression frequently exhibit lower serum zinc levels than healthy controls [501, 502] and a positive correlation exists between zinc deficiency and depression severity as these studies show among female students, postmenopausal women, and hemodialysis patients [503,504,505]

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