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In contrast, drugs such as Wegovy and Zepbound have shown an ability to produce weight loss almost to a similar extent as bariatric surgery

First, the expression of GLP-1R remains controversial in many types of cells and tissues due to the lack of specific antibody against GLP-1R

Choosing between natural pathways, compounded medications, or combination approaches depends on clinical factors: baseline BMI, comorbidities, baseline GLP-1 response biomarkers, and genetic predispositions

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However, as their use becomes more widespread, there has been an increase in patients seeking cosmetic intervention due to treatment-related facial changes [1]