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(3) development of next-generation GLP-1 receptor-targeted therapeutics with enhanced specificity and reduced off-target effects [129,130,131,132]
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In PIONEER-9, oral semaglutide induced nausea in up to 10% of patients, whereas none of the liraglutide patients had nausea (liraglutide was low-dose however) ( Finally, in a network meta-analysis, several short- and long-acting GLP-1RA were compared regarding efficacy and side effect profile
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