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As a synthetic 39-amino acid peptide, Retatrutide acts as a single-sequence multi-agonist with targeted structural affinity for three distinct metabolic pathways: the Gastric Inhibitory Polypeptide (GIP) receptor, the Glucagon-Like Peptide-1 (GLP-1) receptor, and the Glucagon receptor (GCGR)
The results from this landmark study across 37 countries provide strong evidence that semaglutide can help patients with MASH by not only improving liver health, but also addressing the underlying metabolic issues that contribute to the disease, said Sanyal, who is the lead author on the new paper and is also a professor of medicine at the VCU School of Medicine
A provider-guided evaluation of these factors supports more confident treatment selection and dose optimization