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However, their efficacy has limitations, particularly in patients with morbid obesity, where they may not produce enough weight loss to control or resolve the disease fully

doi:10.1056/NEJMoa2505669

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For example, non-obese healthy people can metabolize lipids and glucose efficiently, so the immunomodulatory effect is reflected in immune cell subset migration, lower inflammatory factors, upregulation of circadian rhythmrelated gene expression, and greater microbial diversity

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