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During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

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PMID: [29155147]

Do not give to puppies younger than 10 weeks of age or to dogs weighing less than 4 pounds