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Butyrate counteracts this by inhibiting HDAC to promote regulatory T-cell (Treg) differentiation, reducing autoantibody production, and indirectly preserving cholinergic signaling (He et al., 2024a)

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Future studies employing sophisticated designs, such as ocular-specific GLP-1 R knockout models, are essential to determine if direct neuroprotective effects can occur independently of systemic metabolic correction