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Limitations of this study include its short 6-week duration, the reliance on self-reported sleep dissatisfaction for recruitment, potential practice effects as both groups showed improvement, and the use of one-tailed significance testing, which can increase the risk of false-positive results

Nature 619 , 371377 (2023)

Additionally, the utilization of UDE containing 1000 M -EC resulted in a negative impact on cell viability, whereas treatment with 1000 M -EC alone did not exhibit any toxic effects

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